An integrated metabolomic and proteomic approach for the identification of covalent inhibitors of the main protease (Mpro) of SARS-COV-2 from crude natural extractsArticle Published on 2023-01-152022-11-15 Journal: Talanta [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Analysis applied approach baicalein binding carried catalytic characteristic Chinese complementary complex Compound Covalent binder Cys145 database drug target electrophilic Final functional HIS163 HIS164 His41 independent inhibitor inhibitors Ion knowledge M pro M(pro) mass mass spectrometry maturation metabolomic metabolomics Michael molecular dynamics MPro nucleophilic peptide platform polyprotein protease protein-ligand Proteins proteomic proteomics residue SARS-CoV-2 SARS-CoV-2. Scutellaria baicalensis tested the SARS-CoV-2 [DOI] 10.1016/j.talanta.2022.123824 PMC 바로가기
A stochastic inventory model of COVID-19 and robust, real-time identification of carriers at large and infection rate via asymptotic lawsResearch article Published on 2023-01-012022-10-05 Journal: European Journal of Operational Research [Category] 변종, [키워드] affecting Asymptomatic asymptotic Care carrier COVID-19 COVID-19 incidence COVID-19 pandemic Critical data-driven deaths distribution Epidemic modeling Evolution fraction Health incidence infection rate Little's law management manifested Measures National Operations management under uncertainty OR in health services Outbreaks Patient Perspective profiles provide random Randomly reconstructed robust scaled Spread symptomatic carrier the disease the mean the SARS-CoV-2 trajectory variable variables [DOI] 10.1016/j.ejor.2021.12.037 [Article Type] Research article
A comprehensive review of SARS-CoV-2 vaccines: Pfizer, Moderna & Johnson & JohnsonSARS-CoV-2 백신에 대한 포괄적인 검토: Pfizer, Moderna & Johnson & JohnsonReview Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 변종, [키워드] Adenovirus administration age approval clinical clinical trial clinical trials coronavirus coronavirus. COVID-19 COVID-19 vaccine COVID-19 vaccines effective Efficacy General population group Johnson Johnson & Johnson Johnson & large cohort mechanism moderate Moderna mRNA vaccines Novel coronavirus ongoing trial ongoing trials outbreak pandemic participant Pfizer Safety SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection shown Side effects Spike protein symptomatic SARS-CoV-2 infection tested the SARS-CoV-2 the spike protein the United State Trial United States Vaccinations Vaccine vaccine administration variant [DOI] 10.1080/21645515.2021.2002083 PMC 바로가기 [Article Type] Review
Wastewater to clinical case (WC) ratio of COVID-19 identifies insufficient clinical testing, onset of new variants of concern and population immunity in urban communitiesArticle Published on 2022-12-202022-11-16 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, [키워드] allelic Alpha variant anticipated Canada clinical clinical testing Community complement COVID-19 COVID-19 pandemic decrease Delta VOC diagnostic Effectiveness effort eligibility Endemic epidemiological Epidemiology greater identify Immunity in-depth analysis increases in infection control investigated Metrics occurred omicron Pandemics population immunity proportion public health Public-health reduction reduction in reported required resulting SARS-CoV-2 Seven significant decrease significant increases in significantly Surveillance the disease the SARS-CoV-2 variant variants of concern VoC wastewater wastewater surveillance Wastewater-based epidemiology. [DOI] 10.1016/j.scitotenv.2022.158547 PMC 바로가기
Application of neighborhood-scale wastewater-based epidemiology in low COVID-19 incidence situationsArticle Published on 2022-12-152022-11-16 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, [키워드] application applied approach average characterized Concentration COVID-19 COVID-19 incidence Disease surveillance effective Epidemiology incidence rate infections less limit local outbreak Low COVID-19 incidence Mild N gene Neighborhood-scale sewersheds normalized outbreak plant public health measure quantification reported RT-qPCR SARS-CoV-2 SARS-CoV-2 N gene SARS-CoV-2 variant-specific RT-qPCR assays sensitivity Seven specificity statistically Surveillance the SARS-CoV-2 threshold Treatment virus Wastewater-based epidemiology. [DOI] 10.1016/j.scitotenv.2022.158448 PMC 바로가기
Who complies with prevention guidelines during the fourth wave of COVID-19 in Italy? An empirical studyResearch article Published on 2022-12-012022-10-05 Journal: Personality and Individual Differences [Category] 변종, [키워드] Affect association carried Compliance COVID-19 cross-sectional design dark Dark Triad disease Factor fear functional healthy implication include Italy measure Moderation narcissism pandemic participant Personality positive prevention Protective protective behaviour public health reduce Research Result social distancing Spread the SARS-CoV-2 vaccination variety virus washing hands wearing masks [DOI] 10.1016/j.paid.2022.111845 [Article Type] Research article
Serosurvey in SARS-CoV-2 inactivated vaccine-elicited neutralizing antibodies against authentic SARS-CoV-2 and its viral variantsArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome Administered Antibody neutralization BBIBP-CorV Beta booster vaccination circulating CoronaVac coronavirus Delta Eta Gamma humoral immune response immune immune response inactivated Inactivated vaccine individual Lineage lineages morbidity and mortality Mutation neutralization neutralization titer neutralize neutralized Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody response omicron reduce SARS-CoV-2 SARS-CoV-2 variant second vaccination serum sample significantly lower the SARS-CoV-2 vaccine dose variant viral variant Viral variants Viral variants. virus virus strain viruses wild-type [DOI] 10.1002/jmv.28049 PMC 바로가기
New-onset dermatomyositis following SARS-CoV-2 infection and vaccination: a case-based reviewArticle Published on 2022-12-012022-11-15 Journal: Rheumatology International [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Affect antibodies antibody association autoantibody Autoimmune disease COVID-19 COVID-19 vaccines Defense dermatomyositis Immunosuppressive treatment increase in Infection Intensive Interaction internal organ MDA5 mRNA vaccines occurred pandemic Patient patients positive pulmonary system reported required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. Seven systematic review the SARS-CoV-2 type I vaccination Viral RNA [DOI] 10.1007/s00296-022-05176-3 PMC 바로가기
Initial introduction and spread of the SARS-CoV-2 AY.4.2.1 Delta variant in Bulgaria, a genomic insightArticle Published on 2022-12-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] A222V accelerated Bulgaria COVID-19 pandemic delta variant dissemination Epidemiology Evolution genomic Mutation mutation/mutation rate. mutations raise SARS Coronavirus SARS-CoV-2 variant Spread the SARS-CoV-2 the spike protein Transmission United Kingdom variant [DOI] 10.1002/jmv.28033 PMC 바로가기
Real-world effectiveness of homologous and heterologous BNT162b2, CoronaVac, and AZD1222 booster vaccination against Delta and Omicron SARS-CoV-2 infectionDelta 및 Omicron SARS-CoV-2 감염에 대한 동종 및 이종 BNT162b2, CoronaVac 및 AZD1222 추가 백신 접종의 실제 효과Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] AZD1222 BNT162b2 booster booster vaccination conducted CoronaVac country COVID-19 COVID-19 vaccines Delta demonstrated effective Effectiveness Evidence evidence of Heterologous heterologous booster homologous homologous booster Immune escape inactivated Malaysia National omicron percentage points recipient SARS-CoV-2 SARS-COV-2 infection the SARS-CoV-2 vaccination Vaccine vaccine effectiveness. Vaccines Viral viral variant [DOI] 10.1080/22221751.2022.2072773 PMC 바로가기 [Article Type] Article